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2-(1,2,4-三唑-1-基)喹啉-3-甲酸的制备及其衍生物的合成

时间:2020-07-14 21:51来源:毕业论文
在农业方面具有广泛的应用。咪唑可以作为医药原料,可以制造出抗真菌剂,可以做低血糖治疗药,也是重要的农药原料,是非常重要的有机合成中间体。我们的主要工作是以乙酰苯胺

摘要在医药工业中,许多喹啉、三氮唑、咪唑的化合物都是重要的医药中间体。近年来许多含喹啉环、三氮唑、咪唑衍生物的新型药物被不断开发出来。最近这些年发现,喹啉是有机化学中常见的一种氮杂环的香型化合物喹啉系萘状化合物具有抗肿瘤活性,而且可以应用与农业方面。喹啉可以从煤焦油中提取出来,是通过大孔型强酸性样离子交换树脂方法提取。也可以用苯胺和甘油,硝酸,浓硫酸混合加热的方法制得。也可以通过芳胺、醛、浓盐酸加热制得喹啉衍生物。三氮唑是一种非常重要的化学有机中间体,到目前为止还没有发现天然的化合物,完全依赖于化学有机合成,具有良好的生物活性,化学活性,在医药化工行业具有良好的发展前景,深受研究者们的广泛关注。特别是在农业方面具有广泛的应用。咪唑可以作为医药原料,可以制造出抗真菌剂,可以做低血糖治疗药,也是重要的农药原料,是非常重要的有机合成中间体。我们的主要工作是以乙酰苯胺为起始原料,合成了喹啉母环,以喹啉母环通过经典的取代、氧化反应合成了目标产物喹啉酯衍生物,2(2-(1H-1,2,4-三唑)-3-(苯并[d]咪唑)喹啉)。52397

Abstract In the pharmaceutical industry, many of quinoline compounds and are important pharmaceutical intermediates 。Recent years, quinoline is common in organic chemistry as a nitrogen heterocycle quinoline line of aromatic compounds naphthalene compounds with antitumor activity, and can be applied to agriculture. It can be extracted from coal tar, Is the exchange resin extraction method by macroporous strong acid type ion. and it can be made by using aniline and glycerin, nitric acid and concentrated sulfuric acid. It can also be made by heating the aromatic amine, aldehyde and concentrated hydrochloric acid. Triazole is a kind of very important organic chemical intermediates and so far has not the discovery of natural compounds, totally dependent on synthetic organic chemistry, with good biological activity, chemical activity, in the pharmaceutical and chemical industry has good prospects for development and widespread concern by the researchers. Especially in agriculture, it has a wide range of applications。Nearly imidazole can be used as pharmaceutical raw materials, can produce antifungal agent, can do low blood sugar medicine treatment, it is important to pesticide raw materials, it is very important intermediates in organic synthesis.Our main work is acetanilide as starting materials, the synthesis of quinoline ring, mother quinoline ring through classical instead, oxidation reaction to synthesize the target product quinoline ester derivatives,2 (2 - (1 h - 1,2,4- triazole) - 3 - (benzo [d] imidazole) quinoline).

毕业论文关键词:三唑,喹啉,咪唑 

key word:triazole,quinoline, imidazole 

目录

摘要 2

Abstract 2

目录 3

引言 4

1 喹啉及其衍生物的研究 4

1.1 喹啉的简介 4

1.2 喹啉的合成 5

1.3 喹啉的合成方法 5

1.4 喹啉衍生物的生物活性 6

2 三氮唑及其衍生物进年的研究 6

2.1 三氮唑的简介 6 2-(1,2,4-三唑-1-基)喹啉-3-甲酸的制备及其衍生物的合成:http://www.lwfree.com/yixue/lunwen_56269.html

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